The pregnane x receptor

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August undefined, 2024

Webb1 apr. 2024 · Background. The pregnane X receptor (PXR) is a xenobiotic sensing nuclear receptor that is activated by a diverse array of substances, including environmental … http://www.chinjmap.com/ch/reader/create_pdf.aspx?file_no=231339&flag=1&journal_id=zgyx&year_id=2013

Regulation of mRNA Expression of Xenobiotic Transporters by the ...

Webb10 jan. 2014 · Financial & competing interests disclosure. The authors wish to thank the British Heart Foundation (BS/02/002), the Wellcome Trust (074361/Z/04/Z) and Barts … WebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … highest rated internet news sites

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

Webb12 maj 2024 · The nuclear pregnane X receptor protects against bilateral renal ischemia/reperfusion-induced acute kidney injury in mice. Response to comment on … WebbThe pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma; Cellular Differentiation of … Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, … how has digital technology impacted tesco

The potential use of the pregnane X receptor in cardiovascular …

Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory … WebbPregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation … highest rated internet serviceWebbPXR is remarkably divergent between species, with the rabbit, rat, and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains. … highest rated internet speed test

"WebbBackground: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved … " - The pregnane x receptor

The pregnane x receptor

Activation of Pregnane X Receptor Disrupts Glucocorticoid and ...

WebbThe Pregnane X Receptor. Pregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating … WebbWe studied in mice and human adenocarcinoma-derived Caco-2 cells the impact of low calcium on markers of inflammation (cyclooxygenase-2; COX-2), of detoxification (pregnane and xenobiotic receptor (PXR)/steroid and xenobiotic receptor (SXR), cytochrome P450 steroid-inducible 3a11 (CYP3A11)), and on expression of the vitamin D …

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WebbBackground: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme … Webb1 dec. 1999 · Two of these sites, FP3 (bases -7738 to -7715) and FP4 (bases -7698 to -7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). …

WebbPregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer … WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse …

WebbThe pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, … プレグナンX受容体（プレグナンXじゅようたい、英: pregnane X receptor、略称: PXR）は、ヒトではNR1I2遺伝子によってコードされるタンパク質である。SXR（steroid and xenobiotic sensing nuclear receptor）、NR1I2（nuclear receptor subfamily 1, group I, member 2）の名称でも知られる。

WebbPregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating enzymes, and phase III …

WebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 … highest rated internet securityWebb1 juli 2024 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including … highest rated internet routerWebb1 feb. 2024 · The pregnane X receptor (PXR) is a nuclear receptor which regulates drug metabolizing enzymes (DMEs) by activation from endogenous, as well as exogenous, … how has darren soto used his time in officehttp://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh how has dimmesdale\u0027s appearance changedWebbPregnane X receptor Function . PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by... Ligands . PXR is activated by a … highest rated internet radioWebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains … highest rated internet provider in my areaWebb29 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily [].As part of the … how has digital technology changed the world