The lysosomal rag-ragulator complex

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August undefined, 2024

Splet28. jun. 2024 · The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. 星级： 14 页. RIPK1 suppresses apoptosis mediated by TNF and … SpletA genome-wide CRISPR screen to uncover mediators of caspase-8–dependent pyroptosis identified an unexpected role of the lysosomal folliculin (FLCN)–folliculin-interacting …

The Rag-Ragulator Complex Regulates Lysosome Function and …

Splet07. jul. 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth in eukaryotic cells. The active mTORC1 promotes cellular anabolic processes including protein, pyrimidine, and lipid biosynthesis, and inhibits catabolic processes such as autophagy. Consistent with its growth-promoting functions, hyper … http://www.bio-review.com/rag-ragulator/ buggy seat antiques ohio

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SpletLysosomal FLCN-FNIP2 interacts with RagA GDP and, together with Ragulator, blocks the exchange of GDP for GTP on RagA, reducing its GAP activity towards RagC. Upon amino acid stimulation, disassembly of the lysosomal FLCN–FNIP2 complex switches on the GAP activity of FLCN towards RagC, leading to mTORC1 activation [135,137]. SpletThe RRAG heterodimer is tethered to the lysosomal surface by a pentameric protein complex called Ragulator, which is composed of LAMTOR1 to LAMTOR5. ... Intriguingly, … Splet2024年6月25日，中国科学院上海巴斯德研究所刘星团队等人在Science 在线发表题为The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis … crossbow global

The Rag-Ragulator Complex Regulates Lysosome Function and

New mechanism underlying pyroptosis induced by Yersinia infection

Splet10. apr. 2024 · The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia; RIPK1 activates distinct gasdermins in macrophages … SpletThe Rag-Ragulator complex is a central regulator of lysosomal activity Summary Microglia are resident macrophages of the CNS that are essential for phagocytosis of apoptotic … crossbow glassesSplet07. jan. 2016 · The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia Authors: Kimberle Shen Harwin Sidik Stanford University William S. … buggy seat belts

"Splet01. apr. 2010 · DOI: 10.1016/j.cell.2010.02.024 Corpus ID: 2374243; Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino … " - The lysosomal rag-ragulator complex

The lysosomal rag-ragulator complex

Spletscientific article published on 6 January 2016 Splet07. jun. 2024 · The Ragulator complex is a pentamer containing two heterodimers: Lamtor1/p18 wraps around Lamtor2/p14–Lamtor3/MP1 and …

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Splet25. jan. 2024 · The Raptor–TFEB–Rag–Ragulator complex was prepared by incubating 0.48 μM Raptor, 0.59 μM TFEB–Rag GTPases, 1.42 μM Ragulator, 9.5 μM GTP and 9.5 μM … Splet26. jul. 2024 · 细胞焦亡（Pyroptosis）是由炎症小体和下游的效应因子gasdermin D（GSDMD）所介导的【1,2】。. 在被炎性小体相关半胱天冬酶（Inflammasome …

SpletThe lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia Science 2024-06-25 Journal article DOI: 10.1126/science.abg0269 Contributors : Zengzhang Zheng; Wanyan Deng; Yang Bai; Rui Miao; Shenglin Mei; Zhibin Zhang; Youdong Pan; Yi Wang; Rui Min; Fan Deng et al. Show more detail Source : Crossref Splet24. jun. 2024 · 进一步研究发现Rag-Ragulator的功能缺失能够显著抑制complex Ⅱ的形成、RIPK1磷酸化和caspase-8激活，提示Rag-Ragulator作用于complex Ⅱ上游。功能结构 …

Splet25. jun. 2024 · A genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen to uncover mediators of caspase-8-dependent pyroptosis identified an … SpletWe show that RagA and Lamtor4, two components of the Rag-Ragulator complex, are essential regulators of lysosomes in microglia. In zebrafish lacking RagA function, …

Splet25. jun. 2024 · A genome-wide CRISPR screen to uncover mediators of caspase-8–dependent pyroptosis identified an unexpected role of the lysosomal folliculin …

Splet26. jan. 2016 · The Rag-Ragulator complex is best known for its role in activating mTORC1 signaling in response to lysosomal amino acid levels. The Ragulator complex tethers Rag … buggy seat antiques - canal winchesterSplet19. maj 2024 · The Rag GTPase heterodimer does not contain any lipidation motif, and its lysosomal localization is dictated by Ragulator (Figure 1 A; Bar-Peled et al., 2012; Sancak … crossbow global marketplace solutionshttp://www.ebiotrade.com/newsf/2024-6/2024625150353929.htm crossbow giftsSpletNutrients destabilize the Rag-Ragulator interface… Show more A key step in nutrient sensing is the activation of the master growth regulator, mTORC1 kinase, on the surface of lysosomes. crossbow glitchSpletLysosomal Diseases. Encyclopedia of Cell Biology 2024. [DOI: ... Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 2024;614:572-9. ... Murphy LO. GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis.. [DOI: 10.1101/2024.02.22.432209] [Cited by in … crossbow global marketplaceSpletThe Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia Kimberle Shen, Harwin Sidik, William S. Talbot; Affiliations Kimberle Shen Department of … buggy seathttp://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html crossbow goblin