WebJan 31, 2024 · Iron-sulfur cluster assembly enzyme (ISCU) is a Fe-S scaffold protein that is involved in the synthesis and maturation of [2Fe-2S] and [4Fe-4S] clusters. The fact that several enzymes which regulate metabolism and oxidative stress use Fe-S clusters as its integral co-factor makes ISCU a central player in the process. Indeed, research has shown ... WebIron–sulfur proteins are proteins characterized by the presence of iron–sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. …

Iron–sulfur cluster biosynthesis in bacteria: Mechanisms

WebIron–sulfur clusters are ubiquitous in modern biological systems, serving multiple purposes including protein structural stabilization, electron transfer, substrate binding and … WebMay 25, 2024 · Here, we constructed and expressed dominant-negative variants of the primary Fe-S biogenesis scaffold protein iron-sulfur cluster assembly enzyme 2 (ISCU2) in human HEK293 cells. This approach enabled us to study the early metabolic reprogramming associated with loss of Fe-S-containing proteins in several major cellular compartments. diy practse poker table

Noah Gleason - Doctoral Student - Wayne State …

WebIron-sulfur (Fe-S) clusters are present in more than 200 different types of enzymes or proteins and constitute one of the most ancient, ubiquitous and structurally diverse … WebDescription Myopathy with deficiency of iron-sulfur cluster assembly enzyme is an inherited disorder that primarily affects muscles used for movement ( skeletal muscles ). This … WebMany iron–sulfur enzymes contain the cluster near or at the active site, indicating key roles of these cofactors in catalysis ... Under most conditions, E. coli uses a general ISC … diy preacher pad