Ctcf properties
WebJul 19, 2024 · Transitivity of CTCF-mediated chromatin interaction network. (a) Illustration of transitivity. A, B, C denotes three loop anchors at specific DNA regions that occur CTCF motifs and bind CTCF proteins. WebJul 21, 2024 · Our observations on the highly transitive and clustered network structure of CTCF-mediated chromatin loops, together with the co-localization properties of CTCF …
Ctcf properties
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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with cohesin, which extrudes chromatin loops by … See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs … See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and … See more WebA widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers ... Therefore, taken together with other CTCF properties, localization of CTCF to a narrow cancer-associated chromosome ...
WebJan 14, 2024 · The 3D structures of chromosomes in vertebrate cells play a critical role in nearly all nuclear processes, including transcriptional control of gene expression, replication of DNA, repair of DNA damage, and splicing of messenger RNA (1–4).A key player in chromatin organization is the CCCTC-binding factor (CTCF), an 11-zinc finger (11ZF) … WebApr 10, 2024 · How changes in spatial chromatin organization are integrated into the network of molecular mechanisms mediating CD8+ T cell effector functions and memory formation is not well understood. Quon et al. characterize genome interactions accompanying the CD8+ T cell response to infection and find that the DNA architectural …
WebFeb 10, 2024 · The ~10–15% Hoxa7-P2A-eGFP-positive cells (Extended Data Fig. 1c,d) allowed for enough of a dynamic range to identify mutants that decreased or increased CTCF insulating properties. WebFeb 28, 2005 · CTCF is a transcription factor involved in various aspects of gene regulation. We previously reported that CTCF function is modulated by protein kinase CK2. In this report we investigate further the role of CK2 in regulating the transcriptional properties of CTCF. We demonstrate that coexpression of …
WebApr 14, 2024 · Finally, both TE-derived and native loops exhibit similar CTCF-binding properties (Fig. 4a–c) and patterns of activating histone marks (Supplementary Fig. 4). …
WebAug 12, 2024 · This mathematical property of the CTCF grammar led us to hypothesise that divergent and convergent CTCF sites occur at different spatial regimes and that this … highlander union buildingWebEach set also includes a negative control antibody to ensure specificity of the ChIP reaction. The ChIPAb+ CTCF set includes the CTCF antibody, a negative control antibody (normal … how is dna structure related to its functionWebNational Center for Biotechnology Information highlander used 2014WebJan 3, 2024 · After integrative analysis of the three-dimensional chromatin structure, active compartment-associating loops (aCALs) were identified as a signature of high-order chromatin organization in FGSCs, which revealed that CCCTC-binding factor was a major factor to maintain the properties of FGSCs through regulation of aCALs. highlander unmasked monica mccartyWebMay 6, 2013 · CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional … highlander used for sale near meWebProperties. 생물학적 소스 ... (NFRs) at sites occupied by the multivalent factors CTCF and cohesin via direct interaction with CTCF and the cohesin subunit SA2. In addition, BPTF also interacts with c-MYC and plays an essential role in its genomic distribution and biological activity. BPTF is necessary for the survival of c-MYC ... highlander usb portsWebFeb 23, 2024 · Single-molecule tracking experiments link chromatin residence time to CTCF degradation kinetics, which has ramifications regarding architectural CTCF functions. … highlander usa toyota