WebThe neurotoxic side-effects of cisplatin affect predominantly the large, myelinated fibres of peripheral nerves, leading to a sensory neuropathy. Several reports of cisplatin-associated autonomic neuropathy have been published. Autonomic dysfunction however, is caused by a neuropathy of small unmyelinated nerve fibres. WebAug 15, 2024 · Paraneoplastic autonomic neuropathy may occur as a component of paraneoplastic neuronopathy with anti-Hu antibodies in 23% of patients. Autonomic …

Cisplatin-induced autonomic neuropathy: does it really exist?

WebWe report the assessment of motor and sensory behaviors using an electrophysiologic and an histologic approach, in a rat model of cisplatin peripheral neuropathy.Cisplatin was injected intraperitoneally one (3 mg/ kg), two (2 mg/kg), or three (1 mg/kg) times a week up to a cumulative dose of 15 or 20 mg/kg. WebMay 1, 2024 · An autonomic nervous system illness, postural orthostatic tachycardia syndrome (POTS), strongly connected with a prior viral infection, is the most prevalent autonomic diagnosis correlated with... cse citation for computer program

National Center for Biotechnology Information

WebMar 19, 2014 · For cisplatin, evidence of peripheral nerve damage of any grade has been reported in about 60% of patients receiving a total cumulative drug dose ranging from 225–500 mg/m 2. 2 However, ... Autonomic dysfunction is frequently seen in vincristine-treated patients, with evidence of orthostatic hypotension, constipation, and erectile … WebWe conclude that cisplatin probably does not cause autonomic dysfunction, at least not in rats, in doses commonly used and which are known to cause a peripheral, … WebOct 16, 2024 · If the paraneoplastic process involves the CNS, symptoms can include reduced level of consciousness, seizures, impaired memory or cognitive problems, … cse citation of a website